Section I: Evidence Summary
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Osteoporosis: In children, the diagnosis of osteoporosis is based on two criteria: i) the presence of low Bone Mineral Density (BMD) defined as a z-score less than -2.0 on a DXA* scan, and ii) the presence of a significant fracture history (long-bone fracture of the lower extremities, vertebral compression fracture, or two or more long-bone fractures of the upper extremities). *Dual Energy X-ray Absorptiometry (DXA) Scan: Measures bone mineral content per unit of area. In children it is important that results are compared to pediatric reference data and reported as z scores adjusted for the child’s age, sex and height.
Individuals with a physical disability such as cerebral palsy (CP) are at risk for fragility fractures (osteoporosis) secondary to osteopenia from decreased weight-bearing. Other risk factors often co-exist including poor nutrition with decreased calcium and vitamin D intake, vitamin D deficiency from decreased exposure to sunlight and medications that lower bone density (e.g. some anticonvulsants).
Target Population: Children/youth with CP who are nonambulatory and at risk for or have osteoporosis
Target Clinical Providers: Physicians, Therapists and Nurses caring for children/youth with non-ambulatory CP
Three prevention strategies are recommended:
If an individual with CP has a fragility fracture order additional investigations.These can include bloodwork (Ca, Phosphate, Parathyroid Hormone), an X-ray of the fracturesite, and a DXA scan to determine bone mineral density. Ensure adequate nutrition, Ca and Vit D status. Bisphosphonates should also be considered in children although the long-term safety on growing bones is unknown. Bisphosphonates help to build bone density by suppressing bone resorption. Consultation with a bone specialist is recommended. In children, bisphosphonates are typically given intravenously three to four times per year rather than orally.
|Informing evidence-based clinical practice guidelines for children with cerebral palsy at risk of osteoporosis: a systematic review
Authors: Darcy Fehlings1, Lauren Switzer1, Payal Agarwal1, Charles Wong1, Etienne Sochett2, Richard Stevenson3, Lyn Sonnenberg4, Sharon Smile1, Elizabeth Young1, Joelene Huber1, Golda Milo-Manson1, Ghassan Abu Kuwaik1, Deborah Gaebler5
1 Department of Paediatrics, Bloorview Research Institute, Holland Bloorview Kids Rehabilitation Hospital, University of Toronto, Toronto, ON, Canada.
2 Department of Paediatrics, Hospital for Sick Children, University of Toronto, Toronto, ON, Canada.
3 Kluge Children's Rehabilitation Center & Research Institute, University of Virginia School of Medicine, Charlottesville, VA, USA.
4 Department of Paediatrics, Glenrose Rehabilitation Hospital, University of Alberta, Edmonton, AB, Canada.
5 The Rehabilitation Institute of Chicago, Chicago, IL, USA.
Article first published online: 24 November 2011
Developmental Medicine & Child Neurology
Volume 54, Issue 2, pages 106–116, February 2012
© The Authors. Developmental Medicine & Child Neurology © 2011 Mac Keith Press
Systematic Review of Interventions for Low Bone Mineral Density in Children With Cerebral Palsy
Informing evidence-based clinical practice guidelines for children with cerebral palsy at risk of osteoporosis: an update
|Parent Sheet for Dietary Counseling (Calcium and Vitamin D)|
|Vitamin D and Calcium: Updated Dietary Reference Intakes|
|Guide for therapists developing weight bearing programs for children with physical disabilities|
|Health Canada - Vitamin D and Calcium: Updated Dietary Reference Intakes|
|Darcy Fehlings, MD MSc, FRCP(C)||Holland Bloorview Kids Rehabilitation Hospital
Professor of Pediatrics, University of Toronto
|Toronto, Canada||Developmental Pediatrician|
|Lauren Switzer, MSc||Bloorview Research Institute
Holland Bloorview Kids Rehabilitation Hospital
|Toronto, Canada||Research Project Manager|
|Sezgi Ozel, BHSc||University of Toronto||Toronto, Canada||MScOT (candidate), Occupational Therapy|
|Richard Stevenson, MD||UVA Child Development and Rehabilitation Center
Professor of Pediatrics, University of Virginia
|Richmond, VA||Developmental Pediatrician|
|Deborah Gaebler-Spira, MD||Rehabilitation Institute of Chicago
Professor of Pediatrics and PM&R, Northwestern Feinberg School of Medicine
|Blythe Dalziel, PT||Holland Bloorview Kids Rehabilitation Hospital||Toronto, Canada||Physiotherapist|
The American Academy for Cerebral Palsy and Developmental Medicine has developed care pathways to assist the busy clinician. Please submit any advice or constructive feedback to make this pathway more useful.
NOTE: Feedback will be directed to the AACPDM Care Pathway Taskforce to review and consider on a queue 6-month basis.